Trichostatin A stabilizes the expression of pluripotent genes in human mesenchymal stem cells during ex vivo expansion.
BACKGROUND: Mesenchymal stem cells (MSCs) have been considered as ideal cells for the treatment of a variety of diseases.However, aging and spontaneous differentiation of MSCs during culture expansion dampen their effectiveness.Previous studies suggest that ex vivo aging of MSCs is largely caused by epigenetic changes particularly a decline of hist